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This method is known as the “bivariate model” [ ]. Urinary tract infection in infants: Journal of Nuclear Medicine.

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Abstract Background The use of systematic literature review to inform evidence based practice in diagnostics is rapidly expanding. Use of the leukocyte esterase and nitrite tests to determine the need for culturing urine specimens from a pediatric and adolescent population. Comparison of leukocyturia and bacteriuria] Deutsche Gesundheitswesen.

By contrast, tests used to investigate confirmed UTI mainly utilised imaging technologies which are largely subjective in their interpretation, and where diagnostic thresholds are difficult to define. Pyuria and bacteriuria in infants and children. Three items showed strong evidence of an association with the DOR in the weighted analysis.

Gram stain and contrast-enhanced ultrasound and have no generalisability elsewhere. Nitrite screening for urinary tract infection in a Pediatric Emergency Department. Excretory urography and cystourethrography in the evaluation of children with urinary tract infection.

How does study quality affect the results of a diagnostic meta-analysis?

Assessing the quality of randomized controlled trials: Measurement of vesicoureteral reflux with intravenous 99mTc-DTPA compared to radiographic cystography. Evaluation of a screening test for detecting urinary tract infection in newborns and infants.

Canadian Medical Association Journal. Discussion The methodological quality of primary studies remains a significant issue for systematic reviews of diagnostic tests [ 8, ].

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The time delay between the index test and reference standard was more of a problem with these studies than with those on the diagnosis of UTI.

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Potential utility of MRI in the evaluation of children at risk of renal scarring. Conclusion Given the limitations we describe, the results of this study should be treated as hypothesis generating.

For both tests on the diagnosis of and further investigation of UTI weighted analyses showed an association between a number of variables relating to quality of reporting and diagnostic accuracy well reported studies had higher DORs.

A negative urinalysis predicts the absence of acute pyelonephritis in febrile infants. Does routine ultrasound have a role in the investigation of children with urinary tract infection? Combined suprapubic aspiration and clean-voided urine examination in infants and children. Does urinary tract ultrasonography at hospitalization for acute pyelonephritis predict vesicoureteral reflux?

Meta-analyses of studies of the diagnostic accuracy of laboratory tests: This was similar to the situation seen for studies on the localisation of infection. We estimated summary receiver operator characteristic SROC curves using the following equation [ 15 ]:.

Similarly, although a number of quality checklists for diagnostic accuracy studies have been proposed [ 9 ] and there is growing evidence on the effects of bias in such studies [ 10 ], there has been no rigorously evaluated, evidence-based quality assessment tool for diagnostic studies.

National Center for Biotechnology InformationU. A number of the items found to be associated with test performance related to specific test methodologies e. Technetiumm-dimercapto-succinic acid renal scanning and excretory urography in diagnosis of renal scars in children.

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Further work is needed to elucidate the bacteeioscopico of components of the methodological quality of primary studies on the results of diagnostic meta-analyses. Spectrum composition and reporting of details of how children were selected for inclusion in the study was better in these studies than in the studies of the diagnosis of UTI. The value of ultrasonography as a screening procedure in a first-documented urinary tract infection in children.

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Combined use of urinary alpha1-microglobulin and 99mTc DMSA scintigraphy in the diagnosis and follow-up of acute pyelonephritis and cystitis in children. Urinary N-acetyl-beta-glucosaminidase in children with upper urinary tract infection, in relation to Tcm DMSA scintigraphy. Tests for the localisation of infection Only the evaluation of ultrasound for the localisation of infection bacteriosscopico sufficient data to enable the conduct of regression analysis 20 studies [ 48699799 —,,].

As with studies of the diagnosis of UTI, spectrum composition and reporting of inclusion criteria were poor in this group. DMSA studies in infants under one year of age. Imaging of urinary tract malformations: Imagerie et premiere infection urinaire de l’enfant: Competing interests The author s declare that they have no competing interests. For ultrasound for the detection of reflux a variable for bzcterioscopico or not the ultrasound involved a contrast agent was included. The methodological quality of primary studies remains a significant issue for systematic reviews of diagnostic tests [ 8, ].